Bicuspid aortic valve are asymptomatic mostly , but i would like to collecting data about the initial symptoms and sign in adult persons?
Bicuspid aortic valves do not present differently in diabetics compared to normal adults. More information on bicuspid aortic valves and their clinical presentation can be found in the following article: Article Bicuspid Aortic Valve Disease
Great Coughlin,
But I had already read this article,infact I am working on an article of morphological variation with clinical relevance of bicuspid aortic valve.
I want to know individual personal experienced suggestions in the clinic. Hope you got my point of view.
symptoms and signs begin when ther is functional(significant) stenosis usually secondary to accelerated calcification
I think this is a very intriguing question because BAV is a very heterogeneous disease.
The majority of bicuspid valves become calcified with age and diabetes could accelerate this process.
At the present time most available evidence comes from transversal studies or retrospective studies, so we don´t have sufficient information at that point. Here you have the most extensive study to the best of my knowledge including more than 2000 patients from several hospitals. The authors report that diabetes was significantly associated with valve disfunction, either stenosis or insufficiency in the multivariate analysis. Article Prognostic Implications of Raphe in Bicuspid Aortic Valve Anatomy
The problem as I have stated before is the selection bias in transversal studies...
We have recently published a paper in Heart with 852 patients with BAV. (http://dx.doi.org/10.1136/ heartjnl-2017-311560). Diabetes was not frequent in our study, involving less than 8% of patients. In univariate analysis It was significantly different only in cases of AS (11% vs 5,5%) but not AR nor dilation or the aorta. No differences in multivariate analysis.
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