How does ACE gene expression correlate with angiogenesis markers in women with recurrent miscarriage?

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Zein Al-Abideen Douba

The ACE (angiotensin-converting enzyme) gene plays a role in the renin-angiotensin system (RAS), which influences vascular function and angiogenesis. In women with recurrent miscarriage (RM), several studies suggest a possible link between ACE expression and angiogenic markers such as VEGF (vascular endothelial growth factor), FGF (fibroblast growth factor), and angiopoietins:

ACE and VEGF correlation: Increased ACE activity can lead to higher angiotensin II levels, which may stimulate VEGF expression and modulate placental angiogenesis. Dysregulation may impair proper vascularization of the endometrium, contributing to recurrent miscarriage.

Clinical observations: Some studies report that women with RM have altered ACE gene polymorphisms (e.g., I/D polymorphism) associated with reduced angiogenic factor expression, suggesting a mechanistic link. These changes can affect endometrial blood flow and implantation success

Raquel Castellon

Hello! I agree with Zein Al-Abideen Douba. In addition to the involvement of the various angiogenic growth factors that influence the angiogenic processes that are necessary for embryo implantation and development, ACE levels also direct cell survival, something that we demonstrated a couple of decades ago in our studies of the ACE I/D polymorphism. Feel free to text me if you would like more information or to set up a collaboration.