There seems to be a nexus between mastcell dysfunction autism, rigidity, and temperament

1. Following Richard M Sorrentino UnCer-tainty orientation is the prime human motivator - which reverts to opposite CertaintyO in "depression".

RM Sorrentino er al The uncertain mind.

2. To me the homology of UO to sign-tracking seemed plausible which I discussed with Shelley Flagel, Ann Arbor, with the proposal - derived from my view of mast cells as key actors in PNEI-2.0. Another lab in Ann Arbor now showed that mast cell stabilizers would cancel ST-behavior (as depression would).

Lit.:

Thalamic mast cell activity is associated with sign-tracking behavior in rats.

Fitzpatrick CJ, et al. Brain Behav Immun. 2017.

3. T. Theoharides (mastcellmaster.com) has proven the relevance of mast cells for autism SD, with central social communication deficits AND (supposedly) high CertaintyO.

4. My convergent dyn4TAM model proposes an orthogonal anxio-affective space reflecting three of the SEGREGATED CSTC-loops (to dlPFC, ACC, OFC) and a convergence of these near the thalamus for the encounter with paravascular MCs intruding counter-flow via the outside of the basilary artery (e.g. from the lymphatic end curve).

Lit.: see references in:

GRS Treviranus (2017). For Value or for Worth?

- Part 1: Speaking Syllogistic Attractors of Appropriations in a Thought-Action-Mood-Space

- Part 2: A Neuroeconomical Thought-Action-Mood-Space Modulated by (Un-)Certainty as Sign- or Goal-tracking

http://www.hrpub.org/download/20170330/UJP2-19490464.pdf

http://www.hrpub.org/download/20170330/UJP3-19408548.pdf

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