If the reaction takes place without any external agent, it's a spontaneous reaction. If the reaction takes place with the help of an external agent, then it's a non spontaneous reaction and free Energy in which is the enthalpy of the system, is the entropy of the system, and is the Kelvin temperature. If is negative, the reaction is spontaneous. If is positive, the reaction is non-spontaneous. These results lead to a profound statement regarding the relation between entropy and spontaneity known as the second law of thermodynamics: all spontaneous changes cause an increase in the entropy of the universe.