maybe you could try with Davidson fixative protocol, becose formol is very strong  and could hurt your sample

Formalin 10% is a good fixation it is cheaper, the prínciple is proteínas coagulation...

Best regards

For the purpose of Histology, you could perfuse the mice with 10%Formalin while sacrifice. Followed by either 10% Formalin or 30% sucrose solution to the desired lobe or piece of liver.  Later on you could either prefer to go for OCT embedded cryo sectioning or paraffin embedded sectioning.

I Appreciate the valuable comments.

Dear Charith,

would not / Don't want to oppose to all the hints given in the statements of the previous replies/posterings.

But - as usual....it will depend (as it will always "depend")...on the purpose of your study. "Histology" or "histological study" might be a wide field... [I mean: only structure(s)?, different cell types?, compartments and their specific proteins?, substrata produced...like Glycogen?, fibrosis?, etc.etc.].

Paraffin embedding or cryo-fixation/-sectioning?, etc.etc. Minimum autolysis you can expect with perfusion fixation depending on your skills to handle the mice prior to perfusion fixation.

Is - besides e.g. H&E-staining - IHC also planned or thinkable?

As a standard I recommend isotonic, (phosphate-) buffered 4-5% formaldehyde (at least NBF)-solution for either immersion, or specifically modified fixative for perfusion...

For your convenience I would like to add with my post two articles out of my e-library which might be helpful to come to a decision.

Best wishes and regards, Wolfgang

Just to complete my previous reply: 

If you are not familiar with Davidson's Fixative (which was suggested already by Robero Martín Cruz Castán  (Re No 01) I would like to add again 1 article/document (excerpt from )  out of my e-library which might be helpful additionally.

Regards

Wolfgang

Thank you very much Dr Wolfgang H. Muss for the lengthy information.