Dear Avadhesh Oli

Possible mechanisms by which homocysteine may

contribute :-

1.As cause of thrombosis including activation of factor V,

increased oxidation of low-density lipoprotein, and inhi-

bition of plasminogen activator binding and of protein C

activation, or direct damage to the vascular endothelium

( http://www.aamr.org.ar/secciones/circulacion_pulmonar/biblioteca_en_hipertension_pulmonar_en_pdf/etiopatogenia/hipercoagulabilidad_y_trombosis_de_la_vena_central_de_la_retina.pdf)

2.Altered Homocystiene (Hcy) levels may be a risk factor  by causing structural remodeling and therefore causing shallowing of anterior chamber -may be cause of glaucoma and indirectly cause retinal vein occlusion.

( 2. Yuki K, Murat D, Kimura I, Ohtake Y, Tsubota K Reduced-serum vitamin C and increased uric acid levels in normal-tension glaucoma.Graefes Arch Clin Exp Ophthalmol. 2010 Feb;248(2):243-8)

Elevated Hcy could be an add on factor to pre-existing disease and not a sole cause for the occlusion. High Hcy levels are also found in occlusive vasculitis where the cause of inflammation is different but specific vitamine therapy may help to normalize Hcy levels and prevent further complications.

Thanks for your invaluable inputs.

What I am actually interested is the biostatics part of it. It could be some other untested factor like vitamin C or   Zinc or some thing XYZ.

So how the cause effect is established?