Good day house. Please is there an acceptable way of inducing Lesch-Nyhan disease in rats? Administering 6-OHDA (6 hydroxydopamine) is just to disrupt neurotransmitters levels/ neurological disorders associated Lesch-Nyhan Disease; but does not result in increased uric acid which is the major consequence of HPRT-1 deficiency. So, is there a means of inducing Lesch-Nyhan Disease such that the different symptoms will be observed in the rats?

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