Dear All,
I'd like to calculate Reference Dose (RfD) from Reference Concentrations (RfC) to be used in the risk assessment for ingested and inhaled compound.
For inhalation we work as follow
RfD = RfC (mg/cubic meter) * 20 (cubic meter/day) / 70 (Kg) where 20 is the inhaled air volume and 70 is the body weight for adults.
Is it correct? and how can we work on ingested soil or water?
Every help will be appreciated!
Your approach is fine. See: http://rais.ornl.gov/tutorials/toxvals.html
Sections 2.3 and 2.4
If you are interested; we have developed a detailed document, which gives procedures for developing toxicity factors and discusses uncertainty factors; see:
http://www.tceq.texas.gov/publications/rg/rg-442.html
Click on the RG-442.pdf file
You are correct for inhalation. For ingestion see below:
Oral RfD × GI Absorption Factor = RfDabsorbed
Oral Slope Factor/GI Absorption Factor = Slope Factorabsorbed
you are correct. this link can help you.
https://rais.ornl.gov/tutorials/toxvals.html#2.4%20Derivation%20of%20Inhalation%20RfDs%20and%20Slope%20Factors
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