Skeletal muscle possesses considerable regenerative capacity. This is attributed primarily to stem cell-like cells, i.e., satellite cells, that reside in the muscle tissue. They lie between the basal lamina and the plasmalemma of a fiber. Satellite cells can fuse with injured muscle fibers to repair those fibers and can fuse with other satellite cells to replace irreversibly-injured fibers. Muscle regenerates well from injury except for injuries in which the extracellular matrix is severely disrupted, e.g., as in when there is a traumatic loss of tissue such as an IED blast. Muscle regenerates well from injuries induced by exercise/work, eccentric contractions, freezing, toxin injection, ischemia/reperfusion, etc. It may take a month or so but the muscle usually recovers. However, age, impaired inflammatory response, etc. can impair the recovery.