To find out faster and environmental friendly reaction process is very important.
Hi,
Try microwave irradiation:
http://derpharmachemica.com/vol4-iss6/DPC-2012-4-6-2265-2269.pdf
http://sphinxsai.com/2014/vol6pt4/5/(2534-2538)Jul-Aug14.pdf
Here are two articles to answer your question:
IOSR Journal of Applied Chemistry (IOSR-JAC) e-ISSN: 2278-5736.Volume 7, Issue 11 Ver. I. (Nov. 2014), PP 06-15
URL: http://www.iosrjournals.org/iosr-jac/papers/vol7-issue11/Version-1/B071110615.pdf
Another relevant information for your question can be found in this article:
Natural Acid Catalyzed Synthesis of Schiff Base under Solvent-free Condition: As a Green Approach. Can be obtained from:
http://www.scholarsresearchlibrary.com
Hope this helps answer your question.
Professor Yehia Khalil
Yale University
USA
I have not gone through the papers referenced in the earlier answers may be they have some better methods of synthesizing schiff base ligands. However one solvent free method can be a fusion method which is a non–conventional one pot, single step, solvent free reaction in which the reactant (aldehyde or amine) with higher melting point is first liquefied (melted) and then the other reactant with lower melting point is added to the molten state of former.
This method has many advantages:
The high operating temperature required for melting the high temp reactant speeds up the reaction kinetically.
the effective concentration of the reactants are higher as no solvent dilution takes place.
Adding the low melting reactant to a higher melting reactant in its molten form immediately melts the former for a brisk reaction.
Unlike other solvent free methods like mechanical grinding etc, this method has the advantage of involving a solution phase reaction in the molten state.
with a careful control of experiment no work up is needed as both the reactants are completely dissolved or melted and the reaction conditions are quite favorable kinetically (liquid phase and high temperature reaction).
Most importantly schiff condensation reaction is reversible with respect to hydrolysis by the released water since in fusion method the operating temperatures mostly are above 100 0C so the produced water evacuates in the form of steam.
only care has to be that the compound does not flash before melting and the properly selected smaller glass wear and protective gear should be used before the try.
attached is one pdf in which fusion method has been mentioned
https://www.researchgate.net/.../51046716_Solvent-Free_Synthesis_of_Chiral_Schiff-Ba...
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