Dear colleagues, I am planning to use glovebox for synthesis with air sensitive reagents, which include solid and liquid. Do you have tips/handbook/reference for long hour work? Thank you for your contribution and wisdom!
1. Set up the reaction vessel with all the necessary reagents prior to introducing them into the glove box. 2. Utilize automated syringe pumps to accurately dose reagents, solvents and catalysts into the reaction vessel. 3. Use magnetic stirring bars to ensure efficient mixing and reaction of the reagents. 4. Utilize a heating mantle or hot plate to maintain reaction temperatures. 5. Use online monitoring equipment to track reaction progress. 6. Use inert gas purging to remove oxygen from the reaction vessel. 7. Utilize a quick-change system to switch between different reaction vessels when needed. 8. Utilize a glove box robot to transfer solvents, reagents and products between vessels. 9. Utilize a nitrogen blanket or inert gas sparging to keep the reaction environment anaerobic. 10. Use a glove box that is equipped with a vacuum port to facilitate efficient solvent removal.
- Badges
- Science topic