How can we get evidence for absence of an interaction between rubber closures and sodium chloride parenteral solution?

Andrii V. Proskochylo @Andrii_Proskochylo

11 November 2014 1 6K Report

Dear researchers and guests!

I need a substantiation (methodology) to prove that there are not any interactions between rubber stopper and parenteral solution of sodium chloride. I look forward to any useful comments.

Sridhar Vadahanambi

Read ISO 8871 standards ""Elastomeric parts for parenterals and for devices for pharmaceutical use".

Check your parenteral solution for any visible contaminants leaching out of stoppers.. either by DLS or UV-vis.. secondly check FTIR to detect any chemical changes..

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Science method

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