How can we estimate the number of carboxyl groups on CNT surface by doing Titration method?
In an acid-base titration, the important information to obtain is the equivalence point. In a potentiometric acid-base titration, an indicator is not necessary. A pH meter is used to measure the pH as base is added in small it can be calculated for the equivalence point if the molarity of the base and the volume of base added are known. we might estimate the number of carboxyl groups on CNT surface by doing potentiometry titration method.
Titration means that you add strong acid untill your carboxylates all became protonated in a non-buffered solution. After that your solution became acidic, which is visible by an indicator with appropiate pH range. By the used amount of solution of the acid you can calculate the amount of carboxyl groups.
In an acid-base titration, the important information to obtain is the equivalence point. In a potentiometric acid-base titration, an indicator is not necessary. A pH meter is used to measure the pH as base is added in small it can be calculated for the equivalence point if the molarity of the base and the volume of base added are known. we might estimate the number of carboxyl groups on CNT surface by doing potentiometry titration method.
Better approach is to first fully protonate the carboxylic groups. Some maybe bound to cations other than H+. You may wash several times e.g. with mM HCl. So you know H+ concentration in liquid and can then determine all H+ bound and in solution by titration with e.g. NaOH solution.
Thank You, Dr. Titus for your suggestion. When doing titration method, equivalence point is mainly calculated and by that we can get. But, how can we get through protonating (protonate) the carboxylic groups...
protonated carboxyl groups can be determined by titration. So best to ensure that all carboxyl groups are protonated. Titrating the dispersion in mM conc of HCl gives you then carboxyl groups + H+ of HCl, which is known.
You can follow the protocol mentioned in:
Int J Pharm. 2015 Nov 10;495(1):551-9. doi: 10.1016/j.ijpharm.2015.09.016. or can mail to the corresponding author.
- Badges
- Science topic
- Similar topics
- Chemistry
- Nanotechnology