How can we calculate pn/ps ratio using polymorphism analysis for MSA of orthologous sequences?

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Mahadev Asaram Jadhav

Pn/Ps (relative abundance of non-synonymous and synonymous polymorphisms) that measure the direct effect of natural selection removing slighlty deleterious non-synonymous variants.

The dN/dS ratio was originally developed for application to distantly diverged sequences, the differences among which represent substitutions that have fixed along independent lineages.

for pn/ps calculation plz refer the link mention below

http://www.lifesci.susx.ac.uk/home/Adam_Eyre-Walker/Website/Publications_files/BierneMBE04.pdf

Prashant Kumar

i want to know whether we can calculate pn/ps value of a given FASTA format or not?

Definitely, u can calculate pn/ps value of sequence is in standard FASTA format.

one thing i want to know that lower pn/ps value means more chances of putable drug target?