I want to incorporate the amino functional groups at the end of PHA unit through amination of ester groups. So, how does it possible?
David Jensen
Take a look at this reaction scheme:
http://www.organic-chemistry.org/abstracts/lit3/507.shtm
After the formation of the amide bond reduction using LiAlH4 will result in a secondary amine.
Alternatively, you can look for other generic approaches that involve the amidation of ester bonds. This the reaction produces an amide bond as shown these can always be reduced to amine via LiAlH4, albeit, LiAlH4 will also reduce other oxygen types of bonds to alcohol groups.
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Madhukar Baburao Deshmukh
First convert an ester into amide on treatment with ammonia & then reduce amide by LiAlH4 in Dry ether.
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