Hi.,

There is a basic observation that similar sequences from the same evolutionary family often adopt similar protein structures, which forms the foundation of homology modeling. So far it is the most accurate way to predict protein structure by taking its homologous structure in PDB as template.

Protein secondary structure refers to the local conformation proteins' polypeptide backbone. ... Most commonly, the secondary structure prediction problem is formulated as follows: given a protein sequence with amino acids, predict whether each amino acid is in the α-helix (H), β-strand (E), or coil region (C).

Protein structure prediction by using bioinformatics can involve sequence similarity searches, multiple sequence alignments, identification and characterization of domains, secondary structure prediction, solvent accessibility prediction, automatic protein fold recognition, constructing three-dimensional models