The reactor volume in small scale is 2 ltr., has agitator and sparger .What are the steps to be followed to scale-up the reactor ,so that I can get the product in 10 ltr.in higher amount(~10 times higher)
First you need to define your scale up objectives, whether you are aiming for the same reaction rates, or the same titres. According to your problem, you may choose the latter, so you will aim at keeping the same mass transfer rates (Power/V) for the large scale reactor. A practical scaling-up procedure is described in Geankoplis´book: Transport Processes and Unit Operations, Chapter 3. You can find this book´s pdf in the internet.
Thank you for your reply.
I will surely go through the book and ask you more about this
agitator speed can be calculated as follows
Scale-up Ratio, R = (V2/V1)1/3
Shaft speed scaling is done based on following relation:
N2 = N1 . (1/R)n
From my more practical point of view - a scale-up factor of only 10 is not too high. Depending on the characteristics of your reaction (viscosity? interfaces involved? time scale of transport processes, etc.) as simple geometrical scale-up might do it...
It is very common to use a geometrical scale-up with constant (P/V) or constant tip speed. For sparging, high gas flowrate can lead to impeller flooding or foaming depending on your system. You can keep the same superficial gas flow rate, or volumetrically scale up your gas flows. You can also try enriching the gas (if possible) or increasing the agitation rate to improve mass transfer.
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