Hello,

there is an article ("1,3-Dipolar cycloadditions of MeOPEG-bound azides" by G. Molteni and P. del Buttero - Tetrahedron, 2005, 61, 4983) covering this reaction. They used a polymer supported azide instead of sodium azide and also propargyl bromide. Maybe you can use this, too.

Kind regards,

Simon.

Thanks Dr Simon for your interest and your guide, really i have this article but i want to try to avoid the use of the ploymer and very low yield they got it in this article, so you think it is not easy to do this reaction via simpler way?

Any particular reason you want to do this reaction the hard way? Why not simply react propargyl alcohol with azide, followed by conversion of the alcohol into the bromide using, for example, CBr4/Ph3P. This could probably be run as "one pot reaction" without isolating the intermediate.

Just my 2 cents....

Thanks Dr Frank, really there is no any particular reasons for this and i can try any way to get only the final product. so i will try to do your suggestion .

Dear Hussein Hassan! I suggested you were doing to use desired 1H -4-bromomethyl-1,2,3-triazole  for further modifications. If so, you may substitute Br in propargyl bromide first and thet ttransform ethyn moiety in triazole using a standard CuAAC protocol. Best wishes any way.

could u tell me how much the ratio between propargyl alcohol and cu+2 in click reaction?

hi dear mina.could you plz help me? how can i azide-functionalized graphene oxide?i used your method .but FT-IR analysis is not good,and didnot show peak N3..thanks