Hi,
I am trying to modify sulfonic acid group to conjugate with carboxylic group or amine group in protein.
I have hard time finding chemistry to modify sulfonic acid for the conjugation.
Can anybody let me know if there are options?
Thanks
best,
You can try to convert the sulfonic acid into chloride ( R-SO2Cl) which is more reactive.
Hi Bumjun, I agree with Mikolaj, if you can make a sulfonyl chloride, it will be very reactive with primary amines.
Thanks for the response Mikotaj and Steingrimur.
Could you give me more details? Specific chemistry or literature that I could refer to?
The conditions of reaction depend on the structure of your compound containing -SO3H group. I think that you should check methods using SOCl2 or PCl5. The disadvantage is that these reagents can also react with hydroxyl and carboxyl groups.
okay, I will check it out.
Thank you so much for your advice Mikotaj!
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