I'm dealing with a diverse genus (>50 spp) that contains a great deal of cosmopolitan fungal species, and I have a set of DNA sequences of one to three genes. I would like to know if there is a way to quantify the distance between populations from different countries on different continents (and see if I can relate the geographic distance to genetic distance). It seems obvious that using Euclidian distances is biologically meaningless. How can I compare populations of a species that is distributed in, say, France, India, and South Africa (just to give an extreme example)? Is there a way to consider biomes? How can I account for them moving across the ocean?

I think my question is rather complex, but I would love to hear all sort of opinions and suggestions.

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