I'm trying to define impact of substituted cathinones on depression. To my surprise, majority of my patients who use substituted cathinones are also using many other substances, but I have no detailed data about patients' other drugs usage except for the names of substances. I have detailed data on how often they take the cathinones though, therefore I want to divide the substances into 2 or 3 groups based on these substances' impact on depression for analytical reasons. I don't want to miss any approach during analyzing.
The full list I asked them about contains alcohol, marihuana, amphetamine, meth, MDMA, cocaine, ketamine, LSD/DMT/psylocybine and 2C phenethylamines and "others".
I thought about dividing them into stimulants, depressants and psychedelics, which seems the most reasonable fragmentation to do. Any thoughts?
Thank you!
Hello, Gnieuwko,
Dividing by effect class is probably how most authors have written about them. Since we know as much as we do about the pharmacodynamics of these drugs, it might be interesting to try sorting them according to their effects on transmitters and receptors. For example, ketamine and their analogs are NMDA antagonists, and some are dopamine agonists, and even more likely to both briefly help depression, but then to aggravate it if psychosis is precipitated.. Cocaine and the amphetamines are re-uptake inhibitors of all the monoamines with short duration of action; they cause euphoria briefly, followed by potentially profound depression. Approaching the so-called hallucinogens in that way, comparing and contrasting their pharmacodynamics might be fun. I'll look forward to your efforts.
Dear researcher,
https://www.ncbi.nlm.nih.gov/books/NBK45574. This review may be helpful to you.
Regards
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