Dear vikas,

                 I also face similar problems with some of my synthesized compounds.herewith i am sharing some articles i collected regarding this problem. 

http://pubs.rsc.org/en/content/articlelanding/2015/cp/c4cp05414h#!divAbstract

http://pubs.rsc.org/en/content/articlelanding/2013/cp/c3cp53791a#!divAbstract

http://pubs.acs.org/doi/abs/10.1021/jp309819r?journalCode=jpcbfk&quickLinkVolume=116&quickLinkPage=14915&selectedTab=citation&volume=116

Kindly go through 

J.Du Perez. W.yang 2003 Improving the aqueous solubility of Triclosan by solubilisation, complex action and in situ salt formation. ....J.Cosmet.Sci.

Dear Sahu,

In my toxicological experiments with common carp and trout in Germany I had similar task. I was advised to use acetone as solvent. The procedure is very simple. You know that in experiments with toxic compounds you use very low concentrations. If you dissolve 0.1 or0.5 g pesticide in 1 L of water and use it for further preparation of experimental water, that will be enough to conduct a couple of acute toxicity or a few of chronicle toxicity experiments.

Very small quantity of Triclosan – e.g. 100 mg you can easily dissolve in 0.5 mL of acetone and further dissolve this solution in 1 L of distilled water. This mother solution will have pesticide concentration of 0.1 mg/L. The necessary quantities of this solution you can dissolve further in experimental aquariums. In this case the acetone concentration in aquariums will be almost zero and will not have any toxic effect on fishes.

I hope this will help you.

Bakhtiyor

Dear Sahu,

The mother solution will have 0.1 mg/mL of Triclosan (not 0.1 mg/L). Please, excuse me for mistake.

Bakhtiyor

Could we make solution of triclosan in methanol and then further dissovle it in water for further dilution ?

Dear Rida, In my toxicological experiments with common carp and trout in Germany I had similar task. I was advised to use acetone as solvent. The procedure is very simple. You know that in experiments with toxic compounds you use very low concentrations. If you dissolve 0.1 or0.5 g pesticide in 1 L of water and use it for further preparation of experimental water, that will be enough to conduct a couple of acute toxicity or a few of chronicle toxicity experiments. Very small quantity of Triclosan – e.g. 100 mg you can easily dissolve in 0.5 mL of acetone and further dissolve this solution in 1 L of distilled water. This mother solution will have pesticide concentration of 0.1 mg/L. The necessary quantities of this solution you can dissolve further in experimental aquariums. In this case the acetone concentration in aquariums will be almost zero and will not have any toxic effect on fishes. I hope this will help you. Please, inform me on the result. Bakhtiyor