Is it possible to determine the position of a single calcium ion or its population in the context of a three dimensional space with relatively good time frequency, say 1 Hz, taking into account possible dense presence of the other types of ions in the neighborhood?
The question is asked in the strong relation to the nervous system, but any pure-theory or computer-simulation driven concepts are also welcome.
might help www-physics.lbl.gov/~spieler/misc_stuff/NSS2004/Summary1003.pdf
From a theoretical point of view, you need to do this using stochastic simulations for chemical kinetics in 3D. Some software Neuroscience specific that can model Ca dynamics are (you will have to explore which suits you best):
Steps https://groups.oist.jp/cnu/software
MOOSE http://moose.ncbs.res.in/
NeuroRDS http://krasnow1.gmu.edu/CENlab/software.html
Neuron RXD http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3828620/
Hope this helps.
Two-photon fluorescent microscopy with computer data analysis and imaging, as developed by the Optics department of the University of Rochester (USA)
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