How can I convert Gabalactam to Gabapentin with hydrogenation method?

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Marcin Budny

Opening gabalactam to gabapentin under acidic conditions (i.e. conc. HCl, 24 h, 100 °C) is, I guess, the simplest method. Hydrogenation will reduce something in your molecule, and then you will not receive amino acid.

See: http://dx.doi.org/10.1002/anie.201207803 or http://dx.doi.org/10.1002/chem.201204270

Adel Amer

The transformation needs hydration not hydrogenation