How can I convert bromo to isopropyl on pyrazole 4th position? Can anyone suggest ?

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Basil Mohammed Ahmed

You have to have the 1st, 3rd and 5th position of the pyrazole protected then you can remove the bromide by using BuLi and then react it with isopropyl. It will give you low yield but it will react.

Indrasena Reddy Kummetha

If NH is free on Pyrazole, protect with Boc anhydride and then do Suzuki in presence of EtOH:Toluene (1:1) as a solvent, K2CO3 and tetrakis.