I tried suziki coupling with isopropyl boronic acid and negishi coupling with isopropyl zinc bromide.sm is major
Can you tell me what are the conditions of your reaction?
You have to have the 1st, 3rd and 5th position of the pyrazole protected then you can remove the bromide by using BuLi and then react it with isopropyl. It will give you low yield but it will react.
If NH is free on Pyrazole, protect with Boc anhydride and then do Suzuki in presence of EtOH:Toluene (1:1) as a solvent, K2CO3 and tetrakis.
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