You can use the sample size formula for simple random samples. This requires to establish the prevalence of the study variable, the confidence level of the test (95%) and the margin of error (between 3 and 7%). if you are going to compare groups, it is also necesary to consider the design effect.
edx.org has a free course currently on Fundamentals of Clinical Trials. Week 6 is about sample size calculations. The course is finished so you will need to register soon to have access.