I have done LD50 of a compound. But need to determination of scientifically proved safe dose from it.
LD stands for "Lethal Dose". LD50 is the amount of a material, given all at once, which causes the death of 50% (one half) of a group of test animals. The LD50 is one way to measure the short-term poisoning potential (acute toxicity) of a material.
Toxicologists can use many kinds of animals but most often testing is done with rats and mice. It is usually expressed as the amount of chemical administered (e.g., milligrams) per 100 grams (for smaller animals) or per kilogram (for bigger test subjects) of the body weight of the test animal. The LD50 can be found for any route of entry or administration but dermal (applied to the skin) and oral (given by mouth) administration methods are the most common.
This online calculator is used to determine and graph the LD50 (median lethal dose) value given a set of experimental data.
I have to calculate a safe dose from LD50. Lower dose may be a safe dose, but which maximum lower dose will be accurate? That is the question?
You have to measure the margin of safety, which means the differences between the effective dose and the lowest dose that cause toxicity
You have to perform a dose-response relationship using doses below tose that cause toxicity
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