There is a problem with simultaneous variation of the structure (production equipment) and variation of parameters for each equipment (variation of processing time, reducing time of services, Increasing of priority of working place, ...) by using Design of Experiments .
My suggestion is that we first varies structure in dependence of production cost and achieved annual production. After that we choose best ranked structures for process of parametric optimization.
I would be glad to find out other Procedure or Ideas.
Are there any references for this topic.