I suppose by application of heat you could decompose the linkage to produce NH3,CO and CO2., or by carrying out hydrolysis reaction using strong alkali like NaOH or KOH
Amide hydrolysis can be done on reflux the compound in 10% or above NaOH solution for 1h. It can be done using acid medium, if the aq solution of the compound heated with few drops of concentrated H2SO4.
Details method is available in the 'A Text-book of Practical Organic Chemistry: Including Qualitative Organic Analysis' book by Arthur Vogel
Dear Manish Ramchandani Breaking of amide bond can be achieved by strong aq. base such as NaOH and or/ KOH (about 20% or more) and refluxing for some hours (5- 10h) or using strong acid like H2SO4 (70%) with heating at temp. (50-70 0C) for some hours (6 -8h).
Please check the below links..
https://www.biorxiv.org/content/10.1101/2019.12.17.879908v1.full.pdf
http://nvlpubs.nist.gov/nistpubs/jres/29/jresv29n5p315_A1b.pdf
https://www.sciencedirect.com/science/article/abs/pii/000629528490176X
Thank you for response but a forward query is it same for all molecules (polar/non-polar) or depends.
Manish Ramchandani Manish Ramchandani yes, the reaction rate depends on the reactants. However, most of the amides follow this hydrolysis reaction.
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