I agree completely with Martin Lindhardt Nielsen. Chronic stress can cause ischemia of internal organs, no doubt. Particularly affected are the organs that already have damaged blood vessels (in this case diabetes + infection). In the area of ischemia by existing infection on the high blood sugar level background, in addition to microcirculation impaired , ischemia presence, reduced local and systemic immunity defence (especially suffers macrophage system) we have no reason for good prognosis, excellent treatment compliance or adherence.
I know a syndrome consists of infections and diabetes and allergic reactions. This syndrome is ADA (adenosine deaminase ) deficiency.
Work stress (and probably other stressors) is a risk factor for developing diabetes. So stress is probably also a risk factor of a poor prognosis/complications (this is also a clinical experience, as stressed individuals often have less compliance with recommended lifestyle and treatment). See e.g.:
Kivimäki M, Virtanen M, Kawachi I, Nyberg ST, Alfredsson L, Batty GD, Bjorner JB, Borritz M, Brunner EJ, Burr H, Dragano N, Ferrie JE, Fransson EI, Hamer M, Heikkilä K, Knutsson A, Koskenvuo M, Madsen IE, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Siegrist J, Steptoe A, Suominen S, Theorell T, Vahtera J, Westerholm PJ, Westerlund H, Singh-Manoux A, Jokela M. Long working hours, socioeconomic status, and the risk of incident type 2 diabetes: a meta-analysis of published and unpublished data from 222 120 individuals. Lancet Diabetes Endocrinol. 2015 Jan;3(1):27-34.
Nyberg ST, Fransson EI, Heikkilä K, Ahola K, Alfredsson L, Bjorner JB, Borritz M, Burr H, Dragano N, Goldberg M, Hamer M, Jokela M, Knutsson A, Koskenvuo M, Koskinen A, Kouvonen A, Leineweber C, Madsen IE, Magnusson Hanson LL, Marmot MG, Nielsen ML, Nordin M, Oksanen T, Pejtersen JH, Pentti J, Rugulies R, Salo P, Siegrist J, Steptoe A, Suominen S, Theorell T, Väänänen A, Vahtera J, Virtanen M, Westerholm PJ, Westerlund H, Zins M, Batty GD, Brunner EJ, Ferrie JE, Singh-Manoux A, Kivimäki M; IPD-Work Consortium. Job strain as a risk factor for type 2 diabetes: a pooled analysis of 124,808 men and women. Diabetes Care. 2014 Aug;37(8):2268-75.
In the field of psycho-neuro-immunology, stress is also considered a risk factor for infections, impaired wound-healing etc. See e.g.:
The impact of psychological stress on wound healing: methods and mechanisms. Gouin JP, Kiecolt-Glaser JK. Immunol Allergy Clin North Am. 2011 Feb;31(1):81-93. doi: 10.1016/j.iac.2010.09.010. Review. PMID: 21094925 Free PMC Article
And other articles by Kiecolt-Glaser et al.
Stress generally induces an acute phase response (APR) and consequently leads to chronic inflammatory process.This APR acts as arisk factor of complications in diabetic patients which may cause artherosclerosis or cardiovascular complications.
I agree completely with Martin Lindhardt Nielsen. Chronic stress can cause ischemia of internal organs, no doubt. Particularly affected are the organs that already have damaged blood vessels (in this case diabetes + infection). In the area of ischemia by existing infection on the high blood sugar level background, in addition to microcirculation impaired , ischemia presence, reduced local and systemic immunity defence (especially suffers macrophage system) we have no reason for good prognosis, excellent treatment compliance or adherence.
chronic stress indicates chronic hyperglycemia,increased blood pressure, autoimmunity,.. which reflects a acrue producing free radicals and therefore an unbalance between proxydant and antioxidant. this metabolic disequilibrium will lead to damage proteins (DNA), membrane lipids, ......... and cell damage
- Badges
- Science topic
- Similar topics
- Psychology
- Social Psychology