By exposing ester bonds to water, PLA hydrolyzes without the need for catalysis. As a result of the water molecules' hydrogen bonding interaction with the PLA ester bonds, the ester bonds were forced to deflect toward the interfaces, which allowed the water molecules to attack the ester bonds and break the PLA molecular chain, speeding up the degradation process. This caused an increase in mass loss and the appearance of certain micropores on the PLA scaffold's surface. Although there are many and stable water molecules, the pace of hydrolysis is determined by the concentration of ester bonds and acidic products.
The hydrolysis of ester bond in PLA backbone chains created new end group, carboxyl and hydroxyl end group. Poly (lactic acid) (PLA) is well known for their biodegradability and bioresorbable properties and these