Hi every body, is there any way to create thalassemia in the mouse instead of the molecular or genetic way ways ?

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Hiba Riyadh Al-abodi

Article The Molecular Basis of -Thalassemia

Hong Sheng Cheng

Hi Haider,

Considering that thalassemia is a autosomal recessive genetic disorder, using a pharmacological approach(if possible at all) to model the disease is methodologically unsound. The generalizability of your drug-induced model will always be questioned. However, if your objective is to study a subset of the thalassemia complications (i.e. microcytic anemia), you may then use a pharmacological approach like iron deprivation etc.

Haider Al-Dulaimi

Thank you so much