You need to create your own system parameters because a drug molecule is not a standard molecule like protein/DNA. You did not mention the software you are using for this purpose. If you are using gromacs, this link will be helpful. http://www.mdtutorials.com/gmx/free_energy/index.html
a NAMD tutorial for the calculation of binding free energy for a ligand is available at the following link : https://www.ks.uiuc.edu/Training/Tutorials/#fep
The ligand parameters depends of the forcefield that you plan to use.
If you use CHARMM forcefield, you should use Cgenff server (https://cgenff.paramchem.org/commonFiles/newsEvents.php).
If you prefer AMBER forcefiel, you should use ANTECHAMBER and GAFF (http://ambermd.org/antechamber/).
i have read this tutorial mr.Gautier, but there isn't complete description to creating input file such as pdb file (zero.fep). do you understand what i'm say?