Implicit solvent simulation doesn't work in 5.X version. I run it on 4.6
Also, the forcefield I use is AMBER99SB. When you give the pdb2gmx command, this is the 5th option for the choice of forcefield. I am not sure if CHARMM forcefield can be used for implicit solvent simulation.
Also, there are few changes in the .mdp files. For example, you do not use leap frog integrator.
You can also change the integration steps (dt) to 3 fs. (Default is 2 fs). This would improve the performance by 33%.
Dear Rajiv Lakkaniga I want to run a simulation implicit solvent on 4.6 but when I want to run equilibration I get some error such as segmentation fault (core dumped). I use this command :