The US EPA doesn't regulate TOC directly. When water is being treated and later disinfected, organic compounds can become precursors to disinfection by-products, so there are rules on TOC levels in that case, but measurement of the specific THM compounds that are the concern, so the previous answer with 4 mg/L and 2 mg/L applies there and can by misconstrued as a TOC limit. Refer to US EPA Stage 2 DBPR.
Specific VOCs are regulated. Many states in the USA add a layer of regulations on top of EPA though and since we have 50 states, I can't speak for all of them. Some may regulate TOC but California does not. All of these regulations in official form are publicly available on the web.
Different governments worldwide will have their regulations that vary widely, and different industries will have regulations and guidelines as well. For example, in the US, purified water for pharmaceutical use must meet USP 23 and TOC maximum is 0.05 mg/L as previously stated.
There isn't a single answer to your question and the effect on safety of TOC presence in drinking water could depend on how the water is being used, if it is surface water or ground water, if it is membrane permeate, evaporator condensate or sieve filtrate, how or if it will be disinfected, etc.
Perhaps you could re-phrase your question because the way you have written it, there are many answers. My advice is to ascertain the organic compounds that make up the TOC measurement and understand their source and best available technology for removal.