How can I measure MMP-1 protein activity or protein level from liver tissue?

Instead of checking only the mRNA level, I want to check the active protein level of MMP-1 in Liver tissue from mice. How can I do that?

03 March 2021 1,763 2 View

Binary Logistic Generalized Linear Mixed model in SPSS. Is it doable?

I want to analyses the proportion of swimming sperm of three species of fish in two salinities. To analyse the proportion of swimming sperm in a Generalized Linear Model, I would use a Binary...

03 March 2021 2,297 3 View

Looking for Materials with high thermal expansion coefficient and high temperature resistance?

03 March 2021 8,272 1 View

Guidelines for survey (question type) analysis?

Hi. Please tell me what guidelines should i need to follow for questionaries' type research work in India. It is not hospital based work, we are conduction basic institutional based qualitative...

03 March 2021 2,037 3 View

What are the values needed for gabor filter's parameter for cifar10 data?

Hi, I implemented a code to gabor filter cifar10 data but the images after being filtered and stacked are not clear like the original images. I think the problem is in the way I am using the...

03 March 2021 6,317 1 View

Can we block unwanted images during the x-ray prediction?

i am try to classify the x-ray images. During classification , can i block unwanted images (except x-ray image).

03 March 2021 7,100 1 View

No title

03 March 2021 5,360 2 View

What techniques can I use to determine the miscibility of polymer blends?

The term miscibility refers to the single-phase state in thermodynamics. I do not mean the compatibility of different components. To determine the miscibility I know several techniques such as...

03 March 2021 4,107 4 View

Sample dilution for quantitative analysis using ELISA?

If the detection range is in ng/ml but the reference range is in ug/ml for a molecule or protein in serum or plasma .how to dilute and what is the initial volume to be taken for quantitative analysis

02 March 2021 7,670 3 View

The procedure compute?

02 March 2021 5,204 3 View

How to define receptor atoms in MOE?

How can a set/define atoms as being part of the receptor for docking in MOE? I have a covalently bonded ligand-receptor complex, and I would like to perform a docking experiment with the complex...

18 October 2020 9,688 2 View

How do I convert a list of smiles to Name in MOE?

I have a MOE database with molecule codes and smiles that I have to convert to name. What is the easiest way to do this? Thank you.

04 May 2020 6,987 3 View

Where I can find up-to-date tutorials for using MOE molecular dynamics software ?

Tutorial currently available on the website is backdated to 2014, I need to find a recent tutorials (videos) for 2019 versions because the MOE has been developed progressively in the last few years.

27 April 2020 1,309 6 View

Does anyone know appropriate free software or an online soft tool for computational prediction of IC50?

I am currently interested in calculating (computationally) the value of IC50 for some of organic compounds, so if anyone knows any free software or online tool, tell me, please. Also, I have...

09 December 2019 6,184 4 View

Why would molecules or compounds in a database dock outside the wall restraint in MOE?

A dock validation protocol was conducted with the native ligand and an RMSD value less than 2 Angstrom was obtained. The same validation conditions was applied during that of the database (which...

08 September 2019 8,856 5 View

Does anybody have PDF version of MOE manual?

I will highly appreciate if you can share one for program version 2014 or higher.

28 May 2019 5,615 5 View

Does anybody have PDF version of MOE manual?

I will highly appreciate if you can share one for program version 2014 or higher.

04 May 2019 9,172 3 View

How to use RapidMiner to select descriptors for QSAR model?

Hi, I'm working on my final project about QSAR and docking. I used MOE 2015 to create a database with 128 entries and calculate 206 2D-QSAR descriptors. Now I want to select about 6-8 descriptors...

03 April 2019 8,482 5 View

How to fix: QSAR model doesn't show good result when evaluate with external set?

- My QSAR model has correlation coefficient r2 = 0,90 and RMSE = 0,30 (training set: 102 entries), - I did cross validation (Leave-One-Out) and it's also good result: xr2 = 0,86 and xRMSE = 0,36....

03 April 2019 5,418 3 View

Is it possible to predict complexation mechanism between organic molecule and metal via MOE or other software ?

i want to propose mechanism for complexation between organic molecule and metal via computational software.

08 September 2018 2,382 3 View