Dear Dr.

I think this topic is not studied !!!

I hope this article will serve.

Cheers

Abstract

Abstract. This study aimed to detect the levels of osteocalcin in gingival crevicular fluid (GCF) from healthy (≤3 mm sulcus depth and non-bleeding) and diseased sites (≥6 mm probing depth and bleeding) in subjects with adult periodontitis, in order to further investigate its potential as a possible marker of the disease process. Periodontal probing depths, attachment levels and gingival indices were recorded from one healthy and one diseased site in each of 20 subjects with adult periodontitis. Both GCF accumulated in the periodontal pocket or sulci and GCF flowing into the periodontal pocket or sulci over a three-minute interval were sampled. The amounts of osteocalcin in each GCF sample was determined using immunoassays. A mean of 2.34 ng/site (2.7 μg/ml) osteocalcin was found at diseased sites and a mean of 2.47 ng/site (5.47 μg/ml) was found at healthy sites for the accumulated GCF collection method. A mean of 0.17 ng/site (2.17 μg/ml) osteocalcin was found at diseased sites and a mean of 0.14 ng/site (1.85 μg/ml) at healthy sites for the flow method of GCF collection. There were no statistically significant differences between osteocalcin levels in diseased and healthy sites in subjects with adult periodontitis.

http://onlinelibrary.wiley.com/doi/10.1034/j.1600-051X.1999.260409.x/full

Could you be more specific in your question: do you want to know if people tried to identify Vitamin D levels in Gingival Crevicular Fluid (GCF), or in Saliva?

I'll assume your answer is about GCF. And the answer is yes, researchers have studied that. Vitamin D binding protein (DBP) levels have been measured in GCF. There are a couple of studies I found quickly from 2014. If you need more info, hit back.

Querida Doctora tiene alguna conclusión de su pregunta porque me gustaría saber la respuesta exacta.

Saludos, JMVR

Querida Doctora tiene alguna conclusión de su pregunta porque me gustaría saber la respuesta exacta.

Saludos, JMVR

I tried to measure 25-OH-vitamin D3 in saliva samples using TMS. It is very interesting, but it not present there in concentrations at least more than 1 ng/mL.

Many thanks Dr Alexander. If possible please share the protocol.