I am working on PDXs and to monitor tumor progress I bleed my mice every 7 days. I have noticed a wild fluctuation in blast percentage from week to week. Is that normal or should I tweak my technique a little? For example, Week 5 I get 96% blast count in Peripheral blood and week 6 without any treatment it goes down to 40% and then back up to 90% on week 7. Any advice/suggestions would be awesome.
Thanks much