Gut Flora: What is there to the theory that one can "select bacteria in the human gut" (1) to reduce obesity or (2) to increase leanness of the human?
Dennis
Dennis Mazur
Jeffrey Gordon (Washington University) popularised the science behind the association between gut microbes and obesity and has conducted some elegant experiments showing that human microbes can be transplanted into rodent models to cause an increase or loss in weight.
Other research groups have followed this work, some with success and some who have failed to reproduce the findings (e.g. Flint et al), which underscores the complexity of the metabolic association between the microbes and their host.
The work of Jeff Gordon, Ruth Ley, Frederik Bakhead, Patrice Cani, Willem de Vos, Harry Flint and many PIs at the APC Cork all add knowledge to this area.
A pubmed search just from 2017 generates over 100 hits on the subject. A few recent reviews that give good oversight of the subject include
Heiss CN, Olofsson LE. Gut Microbiota-Dependent Modulation of Energy
Metabolism. J Innate Immun. 2017 Nov 8. doi: 10.1159/000481519. [Epub ahead of print] PubMed PMID: 29131106.
Maruvada P, Leone V, Kaplan LM, Chang EB. The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe. 2017 Nov 8;22(5):589-599. doi:10.1016/j.chom.2017.10.005.
Omer E, Atassi H. The Microbiome That Shapes Us: Can It Cause Obesity? Cure Gastroenterol Rep. 2017 Oct 27;19(12):59. doi: 10.1007/s11894-017-0600-y.
Okubo H, et al Gut microbiota as a therapeutic target for metabolic disorders. Curr Med Chem. 2017 Oct 9. doi:
10.2174/0929867324666171009121702.
Li J, et al Strategies to increase the efficacy of using gut microbiota for the modulation of obesity. Obes Rev. 2017 Nov;18(11):1260-1271. doi: 10.1111/obr.12590.
And a review that tackles the impact of maternal weight on the offspring
Zhou L, Xiao X. The role of gut microbiota in the effects of maternal obesity
during pregnancy on offspring metabolism. Biosci Rep. 2017 Dec 5. pii:
BSR20171234. doi: 10.1042/BSR20171234.
Jeffrey Gordon (Washington University) popularised the science behind the association between gut microbes and obesity and has conducted some elegant experiments showing that human microbes can be transplanted into rodent models to cause an increase or loss in weight.
Other research groups have followed this work, some with success and some who have failed to reproduce the findings (e.g. Flint et al), which underscores the complexity of the metabolic association between the microbes and their host.
The work of Jeff Gordon, Ruth Ley, Frederik Bakhead, Patrice Cani, Willem de Vos, Harry Flint and many PIs at the APC Cork all add knowledge to this area.
A pubmed search just from 2017 generates over 100 hits on the subject. A few recent reviews that give good oversight of the subject include
Heiss CN, Olofsson LE. Gut Microbiota-Dependent Modulation of Energy
Metabolism. J Innate Immun. 2017 Nov 8. doi: 10.1159/000481519. [Epub ahead of print] PubMed PMID: 29131106.
Maruvada P, Leone V, Kaplan LM, Chang EB. The Human Microbiome and Obesity: Moving beyond Associations. Cell Host Microbe. 2017 Nov 8;22(5):589-599. doi:10.1016/j.chom.2017.10.005.
Omer E, Atassi H. The Microbiome That Shapes Us: Can It Cause Obesity? Cure Gastroenterol Rep. 2017 Oct 27;19(12):59. doi: 10.1007/s11894-017-0600-y.
Okubo H, et al Gut microbiota as a therapeutic target for metabolic disorders. Curr Med Chem. 2017 Oct 9. doi:
10.2174/0929867324666171009121702.
Li J, et al Strategies to increase the efficacy of using gut microbiota for the modulation of obesity. Obes Rev. 2017 Nov;18(11):1260-1271. doi: 10.1111/obr.12590.
And a review that tackles the impact of maternal weight on the offspring
Zhou L, Xiao X. The role of gut microbiota in the effects of maternal obesity
during pregnancy on offspring metabolism. Biosci Rep. 2017 Dec 5. pii:
BSR20171234. doi: 10.1042/BSR20171234.
Hi Dr Dennis,, there are some suggestions that gut bacteria can influence weight loss. Diet rich in fibre with prevetella and bacteriods ratio can reduce significant weight loss. Gut bacteria can influence food pocessing and it's absorption, insulin insensivity and appetite and effect the weight loss.. Thanks
Hi Dr. Dennis! Our last review on gut microbes perhaps can help to explain some theories about these questions.
Article Obesity and gut microbiota - what do we know so far?
Sincerely
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