I am performing an esterification reaction using "A with -acid chloride + B with alcohol" to get "A - Ester - B". This reaction uses Pyridine to trap HCl gas as Pyridinium Hydrochloride, so that we can easily remove the impurities. Other than Pyridine, is there any reagents I can use which are non-toxic.
(I already reject Triethyl amine, and DMAP).
Any advise in this regard is highly valued.
Thanks.
According the reaction apparatus set up , granular CaO is better and not toxic.
One more note. Despite the unpleasant smell, pyridine is not poisonous. H: 225-302-312-315-319-332 pyridines. Triethylamine smells less unpleasant, but it is poisonous! H: 225-302-311 + 331-314-335 triethylamine. Compared to low molecular weight acid chlorides (e.g. acetyl chloride), however, both are less dangerous.
Regards
Andreas
A friend of mine suggested 2,6-Lutidine. How about that? I googled it, and understood that it is a food additive, moderately toxic.
Hi, Lutidine is rather expencive and I see no advance to other tert.-Amines. Triethylamine is very common and all my students survived!
U can give a alternative try on inorganic bases at low temperature
How about pyrrolidine, piperidine, morfoline and their N-methyl derivatives?
@Abel J S C Vieira: sec. Amines will react with acid-chlorides as well, even better and faster.
As a base, pyridine can be used as the Karl Fischer reagent, but it is usually replaced by alternatives with a more pleasant odor, such as imidazole. Pyridinium chlorochromate, pyridinium dichromate, and the Collins reagent (the complex of chromium(VI) oxide are used for the oxidation of alcohols.
As a base, pyridine can be used as the Karl Fischer reagent, but it is usually replaced by alternatives with a more pleasant odor, such as imidazole. Pyridinium chlorochromate, pyridinium dichromate, and the Collins reagent (the complex of chromium(VI) oxide are used for the oxidation of alcohols.
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