I am synthesizing a compound using di-aldehyde with a tetra hydroxy moeity(2:1 eq respectively) to form di-acetal, and a free aldehyde group on each side. Im getting oligomeric compounds with different number of units each time. Is there any way to control the number of oligomers formed.Is it possible to synthesize a single unit tht consists of 2 di-aldehyde moeity and single tetra hydroxy moeity. If not can i public result with formed oligomer even when the nmr spectra is not so clear because of the more number of protons
Dear Vara Prasad Rebaka, I think this is the area of protection chemistry, where 'solid phase organic synthesis' is applied, sometimes refered as 'Merrifield Strategy'. In brief, you have to attach the di-aldehyde to a solid support, e.g. PS/DVB resin, SiO2, than react the other aldehyde with the tetra-OH, purify, and react again with the di-aldehyde, and you endup with a compound with di-acetals and two aldehyde end groups. For the NMR may be deconvulution will focus the proton signal. My Regards
Dear Dr Vara Prasad Rebaka . I think you can do that by controlling the conditions of the chemical reaction and especially the stoichiometric of the balanced chemical reaction.
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