Formation of Membrane-attack complex (MAC)? Does immune complex plays a role?

11 March 2019 0 2K Report

In the classical complement pathway, C1q can bind to Bacterial-antibody complex, or C1q binds to bacterial in the absence of antibody. so I am wondering is the antibody really playing a role during MAC formation? Does the formation of MAC initiated by classical complement pathway really require the presence of specific antibody in the serum?

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