Probably not enough. We have been using Amphotericin B and variconazole for > 4 months. When switched to oral antifungal relapse would occur. No evidence of immunodeficiency.
If this child relapses after discontinuation of antifungal treatment, possible underlying problems might be:
1. Primary (e.g. chronic granulomatous disease), secondary immunodeficiency or immunosuppression.
2. local anatomical cause.
Lee, and Yen ).[ http://www.sciencedirect.com/science/article/pii/S1319453410001025] wrote that that in a study of 104 patients with preseptal cellulitis over a 15-year period, the most common predisposing etiologies were acute dacryocystitis (32.6%), sinusitis/upper respiratory infection (28.8%), and recent trauma/surgery (27.8%) (Chaudhry and Shamsi, 2007 and Kikkawa et al., 2002). Treatment of underlying causes
3. However, invasive orbital aspergillosis in an apparently immunocompetent host without evidence of local causes was reported by Primegia et al. [http://dergipark.ulakbim.gov.tr/jmid/article/download/5000116082/5000108020] and by Sivak-Callcott et. al. [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1772124/].
It depends on the causative agents, in our experience, we use amphotericin, but if you have seen relapses, you must consider the same aspects that Mohammad comment.
The commentary of Mohammad MD are accurately, amphothericin B are the best in the treatment of sub-dermal mycoses, in this case the relapses are linked to another factor like is mentioned by Mohammad.