For doing in vitro mutagenicity experiment, is it better to use Ag or Fe or Zn ... nanoparticles?
Hi Emad. For in vitro mutagenicity tests it is best to follow the OECD guidelines attached below. I am working on different types of Fe nanoparticles and it is a good choice for in vitro mutagenicity studies. One drawback is the choice of concentrations which need cumbersome dosage screening experiments as Fe plays an active role in cellular metabolism. So higher concentrations of Fe poses significant mutagenicity. Ag and Zn are known to be toxic and mutagenic in different biological systems. Our group has been actively working on them and they are the best nanoparticles to work on in vitro toxicity. Ag being an antibacterial nanoparticle induces genotoxicity and cell death and Zn at high concentrations causes DNA damage.
https://www.oecd.org/science/nanosafety/45910212.pdf
http://www.oecd.org/chemicalsafety/risk-assessment/1948418.pdf
http://www.oecd.org/science/nanosafety/publicationsintheseriesonthesafetyofmanufacturednanomaterials.htm
http://www.ncbi.nlm.nih.gov/pubmed/22960309
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