Cannulation for ECMO involves the placement of large-bore vascular catheters into central veins or arteries to establish access for blood flow through the ECMO circuit. The two primary cannulation configurations are veno-venous (VV) ECMO and veno-arterial (VA) ECMO, each requiring specific cannulation strategies. Here's an overview of the process of cannulation for ECMO and considerations for choosing the appropriate cannulation site.