I am developing a bio-based oral care product intended for human use, aiming to provide both antiseptic properties and teeth whitening effects. Could experts kindly advise on the essential in vitro and in vivo tests required to scientifically evaluate and confirm the efficacy of such a product? Specifically, I am interested in the appropriate microbiological assays to demonstrate antiseptic activity, as well as the dental or enamel-specific tests to assess whitening efficacy. Additionally, what safety and toxicity assessments are recommended for oral application, and what regulatory guidelines should be considered to support claims for human use? Any recommendations on relevant standards, biomarkers, or clinical trial designs would be greatly appreciated.
Studies on Pomegranate Pericarp Extract
- Evaluation of Anticariogenic Efficacy of Pomegranate (Punica Granatum) Pericarp Extract as Natural Mouth Rinse: An In Vitro and In Vivo Study This study evaluated the antimicrobial efficacy of pomegranate pericarp extract (PPE) against Streptococcus mutans and determined its usefulness as an anti-caries mouth rinse.
- Antimicrobial Activity of Pomegranate (Punica Granatum) Pericarp Extract against Streptococcus Mutans- A Source For Natural Mouth Rinse: An In-vitro and In-vivo Study This study assessed the antimicrobial activity of PPE against Streptococcus mutans.
Other Relevant Studies
- In vitro antibacterial activity of some plant essential oils: This study evaluated the antibacterial activity of certain plant essential oils.
- Efficacy of Some Antiseptics and Disinfectants: A Review: This review discussed the efficacy of various antiseptics and disinfectants.
- Comparative Evaluation of Wettability of Chlorhexidine, Betadine, and an Herbal Mouthwash: This study compared the wettability of different mouthwashes, including an herbal option
Researchers and Publications
- *Biomed Pharmacol J*: Published a study on the evaluation of anticariogenic efficacy of pomegranate pericarp extract as a natural mouth rinse.
Phil Geis The antiseptic properties of the natural oral product we are preparing aim primarily to eliminate bacterial germs responsible for oral infections. By reducing the microbial load in the mouth, these antiseptic effects help prevent plaque formation, combat gingivitis, and maintain overall oral hygiene. Utilizing natural compounds with proven antimicrobial activity offers a safer and gentler alternative to synthetic chemicals, promoting oral health while minimizing side effects such as irritation or resistance. Ultimately, this natural antiseptic formulation supports the prevention of common bacterial oral diseases and contributes to fresher breath
Wissam Mazouz
For plaque you will prob need a substantive active kike chlorhexidine or triclosan Article Anti-plaque agents in the prevention of biofilm-associated o...
safer and gentler, minimizing irritation and resistance sound like advertising speak. What safety data do you have and how will you address "resistance"?
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