When i am proceeding in Run calculation in Ansys Fluent, it shows "Run Cannot be started until Validation issues are resolved " What it means? and how to resolve this issue?
This is usually caused by conflicts in your Setup; the exact reason depends strongly on your physics (i.e., laminar flow? turbulence? energy equation?) and the associated variables you are solving for.
Let's make an example: if you are dealing with CFD simulation of a 2D domain, and you want to calculate the temperature field (T, in the following) in all mesh nodes (let's think that you are using a user-defined-function involving T variable), but your energy equation (which creates the T variable itself) is off, then your error is returned.
Another possible reason is related to report files: if you have defined some report files and you are trying to save a variable which is not defined and/or solved for, then there is a mismatch.
Clearly, without further details on your problem is very difficult to give further help.