I am using peptides on magnetic beads for the adsorption of lithium ions. In my pH study, we found that the best adsorption occurs in the neutral pH range. My question is, why does Li+ adsorption to the strongly negatively charged peptide decrease in an alkaline pH? They are oppositely charged, so they should attract each other.
One possible explanation could be the increased formation of OH- ions in a strongly alkaline medium, which may compete with Li+ ions. Alternatively, a strong, negatively charged cloud of peptides in an alkaline medium could create a hindrance shield, impeding effective adsorption.
both statements are very generic I don't have any reference for this.
It would be helpful to receive any insights or references regarding this matter.
How do you make your solution alkaline? There has to be a positive counter-ion to the solution OH(-), and it may be competing with Li(+). You could try to vary the counter-ion (i.e. vary the base you're using) and see if it helps.
Bharat Bhargawa
Your problem may be explained by the nuclear quantum effect. It gives emergent macro properties to systems. Your problem is one of them. I drew the attention of scientists to this.
https://www.researchgate.net/post/Nuclear_quantum_effect_and_hydrogel
It is useless to discuss this issue without experimental details. Therefore, read my articles on this matter.
Preprint Nuclear quantum effect in aqueous micellar surfactant solutions
Thank you, Professor Yuri, and Professor Emanuel for your valuable response.
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