chloroquine and hydroxychloroquine effective as a treatment for COVID-19

Thank you Mohammed I. Rushdi sir.

This cure has been suggested to use on limited basis.

Than what will be the cure for people across the world.

I totally agree with Dr. Mohammed Ismael Rushdi

We do not know the answer yet, as there is no subtantial study to back that up. In a small study from China, not peer-reviewed yet, a small group of mildly or moderately ill people were given hydroxychloroquine, which appeared to ease their symptoms quickly, but more research is needed (as reported by the New York Times, as of yesterday). This study is not peer reviewed yet.

In addition, these are quite toxic chemicals and people should not take anything without their doctors advise.

Thank you Refik Kanjhan sir. Your views on these aspect fit most appropriate, because US has recommended this medicine for emergency situation incase of covid -19 patients treatment. Ya still more research is needed.. thank you for your elaboration.

Sunil Kumar, dear sir., up to the now, everything is under scrutiny and laborious investigations, though, some studies approved off the delineation of such drugs as plausible cures for "some" cases of covid19.

Considering that more than 90% of those who were infected didn't get life threatening symptoms, are there any alternatives to these medications?

Here is Prof. D. Raoult talking (in French) about ontology and epistemological fashions in modern medical research and social values with regard to the use of these medications:

https://youtu.be/_FFeaM2hNhI

Please see the following RG links.

Article Chloroquine and hydroxychloroquine in the treatment of COVID...

Article Use of Hydroxychloroquine and Chloroquine During the COVID-1...

Here is the initial study by Prof. Raoult:

https://www.mediterranee-infection.com/hydroxychloroquine-and-azithromycin-as-a-treatment-of-covid-19/

Where are the final results after 6 days?...

3-4 weeks ago on the F. official air waves, an expert commented such experiments however I didn’t have the document to evaluate the answers given by the expert to the journalist questions. He said that it could have severe side effects including inducing heart problems. He also insisted on the negativity of the test didn’t mean that it was an evidence for a cure and we would need to wait the death rate of the treated patient to understand the effectiveness of these treatments. Negative test = healed?

However, it was not asked if it reduced the possibility of spreading the contamination. I would believe so since the tests gave negative response on the patients. But I would like clarification from experts: negative test = not contagious?

The journalist concluded not to rush in the drug store and said one actually needs prescriptions to get these drugs. Sarcastically, she said that anyway some patients ask prescriptions to their physicians… At the same time they were warning people about fake news.

I am looking forward to reading your comments.

With kind regards

We can't decide it.Doctors and experts will only decide it based on the situation.

Kindly follow this link

Coronavirus and chloroquine: Is there evidence it works?

https://www.bbc.com/news/51980731

FDA Authorizes Anti-Malarial Drugs Chloroquine And Hydroxychloroquine

https://www.forbes.com/sites/rachelsandler/2020/03/30/fda-approves-anti-malarial-drugs-chloroquine-and-hydroxychloroquine-for-emergency-coronavirus-treatment/amp/

Assessment of the effectiveness/benefit:

https://www.researchgate.net/publication/340293105_No_Evidence_of_Rapid_Antiviral_Clearance_or_Clinical_Benefit_with_the_Combination_of_Hydroxychloroquine_and_Azithromycin_in_Patients_with_Severe_COVID-19_Infection

Thank you all RG members for your thoughts on this discussion

HCQ is an interesting molecule. We need additional studies to clarify how this or HCQ modified molecules could function so to give max protection against Cov2. There are key experiments and questions to answer. To my knowledge Cov2 has two major steps of cell propagation and importantly should exist silent forms of Cov2, at post-infection times. Are these molecules nuclear, cytoplasmic, membrane protected or integrated to a cellular RNA/DNA structure?

Cov2 looks to me to express an HIV propagation-like processing style.

Generally speaking this virus should follow the general conception of virus-host cell interaction (Doucas, 2006 Nature Microbiology).

Dear Dr. Kumar, dear all,

Due to the unusual small number of smokers affected, there is an hypothesis that nicotine may be beneficial because it attaches to one of the cells' receptors shared by the virus thus blocking one of the pathways of the Covid (announcement on the official airwaves yesterday around noon).

I understand that one may have not appreciated my previous comment a few weeks ago because it was claimed on the same F. official airwaves that it was “fake news”.

Now that experts have witnessed it*, is no longer a fake news and it will be a starting point for a scientific study…Maybe at some point they will have the kinetics available. There is no posology available yet either... The side effects can be considered to be minor compared to hydroxychloroquine, can’t they? And it is readily available even in the poor countries.

However, since there are no officially recognized medecine available yet, why not utilizing it before having the kinetics or posology?

With kind regards

*see attachment and study

https://doi.org/10.32388/WPP19W.3

I suppose there are a lot of other (non official) solutions among the 90% who did not get hospitalized...

As of now, CQ/HCQ treatment for Covid-19 is only empirical. We need to generate data on the therapeutic efficacy of these drugs in this special indication. Needless to say, one should also keep a close watch on their already known toxicity and weigh the possible clinical benefits against their toxiciy. Such therapeutic balancing may be worthwhile, though not easy.

"I would like to draw yr attention, Pl read 2 articles which appeared in Science Antimalarials widely used against COVID-19 heighten risk of cardiac arrest. How can doctors minimize the danger? By Kelly ServickApr. 21, 2020 , 3:40 PM doi:10.1126/science.abc3816 Coronavirus found in Paris sewage points to early warning system By Christa Lesté-LasserreApr. 21, 2020 , 2:10 PM doi:10.1126/science.abc3799"

Dr Gupta in :Article Heat waves in non-conventional areas, climate change and dis...

thank you G. Havet , A D Paul, G. Havet and Vassilis Doucas for valuable input for emerging medicine of Hydroxychloroquine.

https://andreaskalcker.com/de/coronavirus-special-information-for-physicians-and-researchers/

As a follow-up from my previous comments.

There are no organohalogen molecules in nature.

Not only they are toxic for the most simple lifeform but also for all other. One can refer to the seminal reference “Silent Spring” by Rachel Carson.

They accumulate, they are not biodegradable.

Hundreds of various treatments have been tried but only a few have been advertised and none that the more than 90% who didn’t have live threatening symtoms took and nothing about the lifestyle of the people who were not affected.

I understand that the role of a physician is to assist his patients one way or another to recover from the disease.

What is more important: "Primo non nocere” or to experiment anything that might work and do whatever it takes to maintain life, ie. do everything for the benefit of Medicine rather than for the benefit of the patients.

Also see answer to:

See my answer to this question:

https://www.researchgate.net/post/Does_Chloroquine_and_hydroxychloroquine_work_as_potential_therapies_against_COVID-19_or_any_other_therapies

LATEST UPDATES:

Hydroxychloroquine alone or with Azithromycin for COVID-19: No benefit but increased risk

No significant benefit with Hydroxychloroquine and Azithromycin either alone or in combination on in-hospital mortality in COVID-19 patients in USA. However, increased risk of prolonged QT-interval with risk of ventricular arrhythmias.

References

Association of Treatment With Hydroxychloroquine or Azithromycin With In-Hospital Mortality in Patients With COVID-19 in New York State

https://jamanetwork.com/journals/jama/fullarticle/2766117

Observational Study of Hydroxychloroquine in Hospitalized Patients with Covid-19

https://www.nejm.org/doi/full/10.1056/NEJMoa2012410

Risk of QT Interval Prolongation Associated With Use of Hydroxychloroquine With or Without Concomitant Azithromycin Among Hospitalized Patients Testing

Positive for Coronavirus Disease 2019 (COVID-19).

https://www.ncbi.nlm.nih.gov/pubmed/32356863

Please have a look..

Article Hydroxychloroquine and azithromycin as a treatment of COVID-...

Prof. Raoult, is put on trial before the College of Medicine in Bordeaux.

He is accused of being a charlatan.

Verdict on friday december 3rd,2021.

Prof. D. Raoult accused of charlatanism received a blame for advertising hydroxychloroquine but was not banished.

He has other on going civil trials some for tampering with his results.