Literature says that gene expression of IRS1 & 2 in diabetic mice is lower than in the normal one. Is it possible that these genes are over-expressed in diabetic mice? If yes, then what may be the possible reasons? Does type 1 or type 2 diabetes got something to do something with it?
I think that is very difficult that IRS-1 & IRS-2 could be overexpressed in diabetic mice. Moreover, overexpression of these genes has been associated with increases in tumorigenesis and metastasis (see link)
http://www.ncbi.nlm.nih.gov/pubmed/9815941
http://www.ncbi.nlm.nih.gov/pubmed/17030631
hello, it may possible that their increase in expression of IRS1 and IRS 2 in initially after streptozotocin injection to compensate normal insulin functioning for achieving cells normal glucose uptake. but later on due to deficiency of insulin in STZ induced animal the expression of the IRS1 and IRS 2 was found to reduced.
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